MONDAY, Jan. 31, 2022 (HealthDay News) — There has been an increase in the proportion of extremely preterm infants surviving to discharge, according to a study published in the January 18 issue of the Journal of the American Medical Association.
Edward F. Bell, MD, of the University of Iowa at Iowa City, and colleagues examined survival, hospital morbidities, care practices, and neurodevelopmental and functional outcomes at corrected age 22 to 26 months in 10,877 infants born between 22 and 28 weeks gestational age between January 1, 2013 and December 31, 2018, including 2,566 born before 27 weeks.
Researchers found that 78.3% of infants survived to discharge, representing an increase of 76.0% from 2008 to 2012. Survival to discharge was 10.9 and 94.0 % for infants born alive at 22 and 28 weeks, respectively. Among actively treated infants, survival was 30.0 and 55.8% at 22 and 23 weeks, respectively. Infants born at younger gestational ages had an increased likelihood of all hospital morbidities. Among infants born before 27 weeks, 8.4, 1.5, 2.5, 49.9 and 15.4% had moderate to severe cerebral palsy, bilateral blindness, required hearing aids or cochlear implants, had been re-hospitalized and required mobility aids or other supportive devices by two-year follow-up. Of the 2458 infants who were fully assessed, 48.7, 29.3, and 21.2% had no neurodevelopmental impairment or mild, moderate, and severe impairment, respectively.
“As more preemies survive, long-term outcomes become increasingly important,” write the authors of an accompanying editorial.
Several authors disclosed financial ties to the biopharmaceutical industry.
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